慢性牙周炎患者基础治疗前后血清及龈沟液脂联素水平的变化及临床意义

Changes of adiponectin levels in serum and gingival crevicular fluid before and after basic treatment for chronic periodontitis and and the clinical significance

目的:探讨慢性牙周炎患者基础治疗前后血清及龈沟液脂联素水平的变化及临床意义。方法:36例慢性牙周炎患者(观察组)和同期于我院口腔检查的36例健康志愿者(健康组)为对象,观察组实施基础治疗,比较观察组基础治疗前后及健康组血清、龈沟液脂联素水平、炎症因子[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)]及临床指标[牙周袋探诊深度(PD)、临床附着丧失(AL)、出血指数(BI)]变化,并探讨各观察指标变化的临床意义。结果:观察组治疗前血清脂联素、龈沟液脂联素水平较其治疗后和健康组明显低(P<0.05);观察组治疗前、治疗后IL-6、IL-8较健康组的明显高(P<0.05);并且观察组治疗后PD、AL、BI较其治疗前明显小(P<0.05);此外经Sperman相关性分析显示慢性牙周炎患者脂联素水平与血清、龈沟液炎症因子IL-6、IL-8呈明显负相关(r_1=-0.758、r_2=-0.698,P<0.05);而患者PD、AL值与血清、龈沟液IL-6、IL-8呈正相关(r_3=0.558、r_4=0.598、r_5=0.698、r_6=0.601,P<0.05)。结论:慢性牙周炎患者疾病发生和进展与脂联素水平降低有一定关系,而其发病机制可能与脂联素可降低机体炎性因子表达有关。

Objective:To investigate the changes of adiponectin levels in serum and gingival crevicular fluid before and after basic treatment for chronic periodontitis and the clinical significance.Methods:36 cases of patients with chronic periodontitis(the observation group)treated in our hospital and 36 healthy volunteers(the healthy group)who underwent oral examinations in our hospital during the same period were enrolled in the study,and the observation group were given basic treatment.Changes in adiponectin levels in serum and gingival crevicular fluid,inflammatory factors[interleukin-6(IL-6),interleukin-8(IL-8)]and clinical indicators[periodontal probing depth(PD),clinical attachment loss(AL),bleeding index(BI)]were compared between the two groups before and after treatment,and the clinical significance of the changes was explored.Results:The adiponectin levels in serum and gingival crevicular fluid of the observation group before treatment were significantly lower than those in the same group after treatment and those in the healthy group(P<0.05).The levels of IL-6 and IL-8 in the observation group before and after treatment were significantly higher than those in the healthy group(P<0.05).The PD,AL and BI in the observation group after treatment were significantly smaller than those before the treatment(P<0.05).Sperman correlation analysis showed that adiponectin levels in patients with chronic periodontitis were negatively correlated with inflammatory factors IL-6 and IL-8 in serum and gingival crevicular fluid(r 1=-0.758,r 2=-0.698,P<0.05),while the PD and AL were positively correlated with IL-6 and IL-8 in serum and gingival crevicular fluid(r 3=0.558,r 4=0.598,r 5=0.698,r 6=0.601,all P<0.05).Conclusion:There is a certain correlation between the incidence and progression of chronic periodontitis and adiponectin levels,and its pathogenesis may be related to the decrease of inflammatory factors by adiponectin.