舒必利和氯氮平维持性治疗精神分裂症的两年随访结果

A follow-up study of the maintenance treatment on the schizophrenia with clozapine and sulpiride.

目的 比较舒必利和氯氮平对精神分裂症的维持治疗的疗效及复发。方法 对出院后坚持使用舒必利和氯氮平维持治疗的精神分裂症病人进行了疗效评定 ,并随访 2年。结果 舒必利对精神分裂症阴性症状的改善和社会功能的恢复好于氯氮平 ,且副作用亦少。结论 舒必利维持治疗是改善精神分裂症阴性症状和预防复发比较理想的药物 。

Objective To approach the effect and relapse which is produced by clozapine and sulpiride in the maintenance treatment on the schizophrenia.Method By making a two-year follow-up study on the schizophrenia patients who insist on taking clozapine and sulpiride in the maintenance treatment after leaving hospital.Result In the treatment of the schizophrenia,sulpiride works better than clozapine in restraining the negative symptoms and recovering the social function.And moreover,it leads less by-effects.Conclusion Sulpiride is well worth recommending for it is the relatively ideal medicine to cure the schizophrenia in the maintenance treatment and to prevent its relapse,especially for the negative symptoms restraining.