免疫产生迟发型溶血性输血反应的分析

Analysis of Delayed Allogeneic Hemolytic Reaction Following Transfusion

目的通过检测分析患者血型不规则抗体,选择合适的血液进行输注,防止出现迟发型溶血性输血反应,为临床安全输血提供保障。方法应用经典抗人球蛋白法对不规则抗体阳性患者的血标本进行抗体鉴定,分析特异性。结果在患者血清中检出IgM合并IgG性质抗-E抗体,效价为IgM 32、IgG 128。结论在输血前进行不规则抗体筛查,对阳性标本进行抗体鉴定,首次输血的患者在输血前进行Rh抗原分型(CcEe)检测,对保证患者临床输血安全、降低溶血性输血反应具有重要的意义。

Objective Irregular blood group antibodies were detected in patients to prevent the occurrence of allogeneic delayed hemolytic transfusion reaction(DHTR)and transfusion safety.Methods Classical anti-human globulin test was taken to detect the specific antibodies in the serum of patients.Results The serum titers of IgM and IgG of anti-E were 1:32 and 1:128,respectively.Conclusion Rh antigen(CcEe)typing is necessary in the patients who have primary blood transfusion of red blood cells.Screening of irregular antibodies before transfusion is especially important to reduce the reverse reaction of hemolytic transfusion and ensure the clinical blood transfusion safety.