吉西他滨联合奥沙利铂治疗尿路上皮肿瘤的效果分析

Efficacy of Gemcitabine Combined with Oxaliplatin in the Treatment of Urothelial Tumors

目的探讨对尿路上皮肿瘤患者行吉西他滨+奥沙利铂联合治疗的临床效果。方法方便选取2016年2月—2017年2月该院收治的56例尿路上皮肿瘤患者作为研究对象,根据所采取的治疗方法不同分为联合组和单一组,各28例。单一组仅行吉西他滨治疗,联合组在单一组的基础上联合使用奥沙利铂进行治疗,观察并比较两组治疗效果以及不良反应发生几率。结果联合组的治疗有效率22例(78.57%)显著高于单一组12例(42.86%),联合组的不良反应发生几率1例(3.57%)显著低于单一组7例(25.00%),差异有统计学意义(P<0.05)。结论对尿路上皮肿瘤患者行吉西他滨+奥沙利铂联合治疗,不仅能够在一定程度上减少不良反应的发生,同时,还能够确保整体治疗效果,对于患者肾功能的影响程度较为轻微,更加利于患者的病情恢复。

Objective This paper tries to investigate the clinical effect of gemcitabine combined with oxaliplatin in patients with urothelial tumors.Methods Fifty-six patients with urothelial tumors admitted from February 2016 to February 2017 in this hospital were convenient selected and enrolled in this study.According to the different treatment methods,they were divided into combined group and single group,with 28 cases in each group.The single group only adopted gemcitabine treatment,the combined group on the basis of single group adopted the combination of oxaliplatin treatment,observation and comparison of two groups of treatment and the incidence of adverse reactions.Results In the combined group,22 cases(78.57%)were significantly better than 12 cases(42.86%)in the single group,and 1 case(3.57%)in the combined group of adverse incidence,which was significantly lower than that in the single group(25.00%),the difference was statistically significant(P<0.05).Conclusion Combination therapy of gemcitabine+oxaliplatin in patients with urothelial tumors not only can reduce the incidence of adverse reactions to a certain extent,but also ensure the overall therapeutic effect,which has a slight influence on renal function and is more beneficial to patients’condition to recover.