初诊肥胖2型糖尿病患者血清Betatrophin水平与胰岛β细胞功能的关系

Relationship on Serum Betatrophin Concentration and Islet Beta Cell Function in Patients with Newly Diagnosed Obese Type 2 Diabetes Mellitus

目的探讨初诊肥胖2型糖尿病患者血清Betatrophin水平与胰岛β细胞功能的关系。方法方便选择2014年1月—2015年1月初诊肥胖2型糖尿病患者100例为研究对象(观察组),另选择同期该院体检健康者(NGT)者100名为对照观察(对照组)。测量人体指标,检测相关代谢血生化指标,采用酶联免疫吸附实验(ELISA)法测定空腹血清Betatrophin水平,采用直线相关分析研究betatrophin与胰岛β细胞功能、体测及代谢指标的相关关系。结果观察组血清Betatrophin水平(422.5±247.60)pg/m L明显高于对照组(316.3±293.30)pg/m L,差异有统计学意义(P<0.05);相关性分析提示Betatrophin与腰臀比、HOMA-IR、FPG、2 h PG、HbA1c、FINS、TG呈正相关(r=0.215、0.216、0.249、0.447、0.338、0.452、0.470,P<0.01),与HDL-C、HOMA-β成负相关(r=-0.256、-0.363,P<0.05),差异有统计学意义(P<0.05)。结论初诊肥胖2型糖尿病患者的血清betatrophin水平较NGT组明显升高,并且与胰岛β细胞功能密切相关,推测其参与了糖尿病的发生。

Objective This paper tries to investigate the relationship on serum betatrophin concentration and islet beta cell function in patients with newly diagnosed obese type 2 diabetes mellitus(T2DM).Methods Totally 100 patients with newly diagnosed obese type 2 diabetes in the hospital from January 2014 to January 2015 were selected as the observation group and 100 healthy people at the same period were convenient selected as the control group.Anthropometrics and blood biochemical indexes of metabolism were measured,and serum betatrophin concentration was determined with ELISA.Correlation between betatrophin and anthropometrics and biochemical indexes was linear correlation analyzed.Results Serum betatrophin level was(422.5±247.60)pg/mL vs(316.3±293.30)pg/mL significantly increased in the observation group compared with healthy controls(P<0.05);the correlation analysis suggested that serum betatrophin level in all participants was positively correlated with waist hip ratio,HOMA-IR,fasting plasma glucose,2 h postprandial plasma glucose,glycated hemoglobin A1c,fasting serum insulin,and triglycerides(TG)(r=0.215、0.216、0.249、0.447、0.338、0.452、0.470,P<0.01),and negatively related to the high-density lipoprotein-cholesterol,HOMA-β(r=-0.256,-0.363,P<0.05),with significant difference(P<0.05).Conclusion The serum betatrophin level with newly diagnosed obese type 2 diabetes mellitus is higher,and is closely related with islet beta cell function.It may be involved in the development of diabetes.