奥沙利铂联合不同使用方法5-FU/FA方案治疗晚期结直肠癌的疗效及不良反应对比

Comparison of Curative Effect and Adverse Reactions of Oxaliplatin Combined with Different Use Methods 5-FU/FA Plans in Treatment of Advanced Colorectal Cancer

目的研究奥沙利铂(L-OHP)联合不同使用方法 5-FU/FA(5-氟尿嘧啶-亚叶酸钙)方案治疗晚期结直肠癌的疗效及不良反应对比。方法方便选择于2016年1—12月间该院收治的46例患者参与疗效评价,按照奥沙利铂联合不同使用方法 5-FU/FA用药划分为ArmA方案组与ArmB方案组各23例,分析不同用药方案后治疗效果及不良反应发生情况。结果 ArmA方案组,完全缓解1例(4.35%)、部分缓解14例(60.87%)、稳定7例(30.43%)、进展1例(4.35%);ArmB方案组,完全缓解1例(4.35%)、部分缓解15例(65.22%)、稳定6例(26.09%)、进展1例(4.35%)。ArmA方案组与ArmB方案组完全缓解、部分缓解、稳定及进展百分比结果比较差异无统计学意义(χ~2=0.000、0.406、0.465、0.000,P>0.05)。ArmA方案组,发生恶心呕吐2例(8.70%)、腹泻3例(13.04%)、外周神经毒性反应1例(4.35%)、白细胞减少10例(43.48%);ArmB方案组恶心呕吐3例(13.04%)、腹泻2例(8.70%)、外周神经毒性反应1例(4.35%)、白细胞减少11例(47.83%)。两组不良反应发生率结果比较差异无统计学意义(χ~2=0.972、0.972、0.000、0.381,P>0.05)。结论奥沙利铂(LOHP)联合不同使用方法 5-FU/FA(5-氟尿嘧啶-亚叶酸钙)方案治疗晚期结直肠癌,不同方案用药后取得疗效结果比较无差异;且两组不良反应发生率比较无差异。

Objective To research the comparison of curative effect and adverse reactions of oxaliplatin combined with different use methods 5-FU/FA plans in treatment of advanced colorectal cancer.Methods 46 cases of patients in our hospital from January to December 2016 were conveniently selected and divided into two groups with 23 cases in each,according to different use methods 5-FU/FA medication,including the ArmA plan group and ArmB plan group,and the treatment effect and occurrence of adverse reactions were analyzed.Results In the ArmA plan group,there was 1 case with complete relief(4.35%),14 cases with partial relief(60.87%),7 steady cases(30.43%)and 1 progressive case(4.35%);in the ArmB plan group,there was 1 case with complete relief(4.35%),15 cases with partial relief(65.22%),6 steady cases(26.09%)and 1 progressive case(4.35%);and the differences were not statistically significant(χ2=0.000,0.406,0.465,0.000,P>0.05),in the ArmA plan group,there was 2 cases with nausea vomiting(8.70%),3 cases with diarrhea(13.04%),1 case with peripheral nerve toxicity reaction(4.35%),10 cases with hypoleucocytosis(43.48%)in the ArmB plan group,there was 3 cases with nausea vomiting(13.04%),2 cases with diarrhea(8.70%),1 case with peripheral nerve toxicity reaction(4.35%),11 cases with hypoleucocytosis(47.83%),and the difference in the incidence rate of adverse reactions between the two groups was not statistically significant(χ2=0.972,0.972,0.000,0.381,P>0.05).Conclusion The difference in the curative effect of oxaliplatin combined with different use methods 5-FU/FA plans in treatment of advanced colorectal cancer is not statistically significant,but the difference in the incidence rate of adverse reactions between the two groups is not statistically significant.