PCT与CRP、WBC对全身炎症反应综合征病情及预后的指导作用分析

Analysis of Effect of PCT, CRP and WBC in Guiding the Disease and Prognosis of Systemic Inflammatory Response Syndrome

目的探讨降钙素原(PCT)与C反应蛋白(CRP)、白细胞(WBC)对全身炎症反应综合征(SIRS)病情及预后的指导作用分析。方法回顾性分析该院2016年1月—2017年8月收治的102例全身炎症反应综合征患者临床资料,比较感染组、非感染组,死亡组与存活组患者PCT、CRP、WBC水平的差异,并分析患者急诊脓毒症病死率评分(MEDS)情况。结果 SIRS感染组患者PCT(3.73±0.46)μg/L、CRP(486.56±53.34)mg/L、WBC(12.74±2.26)×109/L水平显著高于非感染组PCT(0.68±0.25)μg/L、CRP(352.27±36.92)mg/L、WBC(10.34±1.64)×109/L(P<0.05);SIRS死亡组患者PCT(4.84±0.65)μg/L、CRP(525.36±58.36)mg/L、WBC(12.95±2.21)×109/L水平显著高于存活组PCT(0.64±0.23)μg/L、CRP(346.35±35.57)mg/L、WBC(10.21±1.58)×109/L(P<0.05);SIRS死亡组患者MEDS(14.47±1.54)分显著高于存活组MEDS(4.36±0.38)分(P<0.05)。结论 PCT与CRP、WBC对全身炎症反应综合征具有较高的诊断价值,有助于鉴别感染性、非感染性,对患者预后也具有一定的参考价值。

Objective To study the effect of PCT,CRP and WBC in guiding the disease and prognosis of systemic inflammatory response syndrome.Methods 102 cases of patients with systemic inflammatory response syndrome admitted and treated in our hospital from January 2016 to August 2017 were selected and divided into two groups,the differences in the PCT,CRP and WBC levels between the infection group and non-infetion group,death group and survival group were compared,and the MEDS of patients was analyzed.Results The PCT,CRP and WBC levels of SIRS infection group were obviously higher than those of non-infection group[(3.73±0.46)μg/L,(486.56±53.34)mg/L,(12.74±2.26)×109/L vs(0.68±0.25)μg/L,(352.27±36.92)mg/L,(10.34±1.64)×109/L](P<0.05),and the PCT,CRP and WBC levels of SIRS death group were obviously higher than those in the survival group[(4.84±0.65)μg/L,(525.36±58.36)mg/L,(12.95±2.21)×109/L vs(0.64±0.23)μg/L,(346.35±35.57)mg/L,(10.21±1.58)×109/L](P<0.05),and the MEDS score of SIRS death group was obviously higher than that of the survival group[(14.47±1.54)points vs(4.36±0.38)points](P<0.05).Conclusion The value of PCT,CRP and WBC in diagnosis of systemic inflammatory response syndrome is higher,which contributes to differential diagnosis of infection and non-infection,which is of reference value to the prognosis of patients.