不同方式给予5-氟尿嘧啶与利多卡因对跖疣疗效的影响

Efficacy of different combinations of 5-fluorouracil and lidocaine in treatment of plantar warts

目的:观察不同方式给予5-氟尿嘧啶(5-fluorouracil,5-FU)与利多卡因对跖疣疗效的影响。方法:将60例患者随机分为对照组和观察组,每组各30例。对照组将2.5%氟尿嘧啶注射液与2%利多卡因按11的比例混匀后注入疣体,每周1次,连用2周;观察组先注射利多卡因,表面麻醉后再注射5-FU,每周1次,连用2周。观察2组患者临床疗效及应用视觉模拟评分法(VSA评分)评价2组患者治疗中及治疗后的疼痛程度。结果:观察组治疗中VAS评分5.00±1.29高于治疗后0.30±0.47,差异有统计学意义(t=18.81,P<0.05);对照组治疗中VAS评分8.60±1.04高于治疗后0.37±0.49,差异具有统计学意义(t=39.31,P<0.001)。观察组在治疗中VAS评分5.00±1.29低于对照组8.60±1.04,差异具有统计学意义(t=-11.93,P<0.05)。2组患者治疗后30 min VAS评分无明显差异(t=-0.54,P>0.05)。观察组痊愈率为66.67%,对照组痊愈率为36.67%,差异有统计学意义(χ~2=5.41,P<0.05);观察组总有效率为93.34%,对照组为86.67%,2组比较差异无统计学意义(χ~2=2.22,P>0.05)。结论:利多卡因局部麻醉后再注射5-FU治疗跖疣的疗效优于5-FU与利多卡因11混合液直接疣底注射,且治疗过程中疼痛程度更小。

Objective:To investigate the efficacy of different combinations of 5-fluorouracil(5-FU)and lidocaine in the treatment of plantar warts.Methods:A total of 60 patients with plantar warts were equally and randomly divided into observation group and control group.The control group was injected with the mixture of 2.5%5-FU and 2%lidocaine(1:1)once a week for 2 weeks.The observation group was first injected with lidocaine to achieve topical anesthesia and then injected with 5-FU once a week for 2 weeks.The clinical outcomes of the two groups were observed.Moreover,the Visual Analogue Scale(VAS)was used to evaluate the pain levels of the two groups during and after treatment.Results:In the observation group,the VAS score during the treatment was significantly higher than that after treatment(5.00±1.29 vs 0.30±0.47,t=18.81,P<0.05).In the control group,the VAS score during the treatment was significantly higher than that after treatment(8.60±1.04 vs 0.37±0.49,t=39.31,P<0.001).The observation group had a significantly lower VAS score during the treatment than the control group(5.00±1.29 vs 8.60±1.04,t=-11.93,P<0.05).There was no significant difference in VAS score at 30 min after treatment between the two groups(t=-0.54,P>0.05).The observation group had a significantly higher cure rate than the control group(66.67%vs 36.67%,χ2=5.41,P<0.05).There was no significant difference in overall response rate between the observation group and the control group(93.34%vs 86.67%,χ2=2.22,P>0.05).Conclusion:Compared with the mixture injection of 5-FU and lidocaine(1..1),5-FU after the local anesthesia with lidocaine in the treatment of plantar warts has better efficacy and causes less pain during the treatment.