生化指标联合检测在肝硬化中的诊断效能

Diagnostic efficacy of biochemical indicators joint test in the diagnosis of cirrhosis

目的探讨生化指标联合检测在肝硬化中的诊断效能。方法选取我院收治的疑似肝硬化患者68例为研究对象,所有患者均行生化指标检测,比较联合检测及单独检测的诊断阳性率及诊断效能。结果 68例疑似肝硬化患者中,病理诊断阳性61例,阳性率为89.71%。丙氨酸转氨酶(ALT)、总胆红素(TBIL)、碱性磷酸酶(ALP)、谷草转氨酶(AST)、γ-谷氨酰转肽酶(γ-GT)、直接胆红素(DBIL)、白蛋白(ALB)、总蛋白(TP)及胆碱酯酶(CHE)联合检出阳性率显著高于单独检测阳性率(P<0.05)。ALT、TBIL、ALP、AST、γ-GT、DBIL、ALB、TP及CHE联合检测的敏感性、特异性、准确性及阳性预测值均显著高于单独检测(P<0.05)。结论各生化指标联合检测可有效提高肝硬化诊断效能,对临床治疗具有重要的参考价值。

Objective To explore diagnostic efficacy of biochemical indicators joint test in the diagnosis of cirrhosis.Methods Sixty-eight patients with suspected cirrhosis admitted in our hospital were selected as the study objects.All the patients were given biochemical indicators joint test,and the diagnostic positive rate and diagnostic efficacy between joint test and single test were compared.Results In 68 cases of suspected cirrhosis patients,the pathological positive in 61 cases,and the positive rate was 89.71%.The diagnostic positive rate of joint test of alanine aminotransferase(ALT),total bilirubin(TBIL),alkaline phosphatase(ALP),aspartate aminotransferase(AST),γ-GT,direct bilirubin(DBIL),albumin(ALB),total protein(TP)and cholinesterase(CHE)was significantly higher than that of the single tests(P<0.05).The sensitivity,specificity,accuracy and positive predictive rate of joint test of ALT,TBIL,ALP,AST,γ-GT,DBIL,ALB,TP and CHE were higher than those of the single tests(P<0.05).Conclusion Biochemical indexes joint test can effectively improve the diagnostic efficacy of cirrhosis,which has an important reference value for clinical practice.