恙虫病发生多器官功能障碍综合征危险因素分析

The risk factorsfor tsutsugamushi disease combined with multiple organ dysfunction syndrome

目的:研究恙虫病发生多器官功能障碍综合征(MODS)的危险因素。方法:收集2000—2010年本院收治的199例恙虫病患者的临床资料,根据是否合并MODS分为MODS组(36例)和非MODS组(163例),采用单因素及多因素Logistic回归分析方法分析恙虫病患者并发MODS的相关因素,包括年龄、性别、慢性基础疾病、发病至确诊时间、确诊前使用激素、热程、炎症血象、血钾异常、血钠异常、血沉、C反应蛋白(CRP)水平。结果:单因素分析结果显示,两组年龄、热程、炎症血象、CRP比较差异有统计学意义(P<0.05);多因素Logistic回归分析显示:热程、CRP是恙虫病并发MODS的独立危险因素(P<0.05)。结论:热程长、CRP升高的恙虫病患者更易发生MODS。

Objective:To investigate the risk factors for tsutsugamushi disease combined with multiple organ dysfunction syndrome(MODS).Methods:The clinical data of 199 patients with tsutsugamushi disease trea-ted in our hospital from 2000 to 2010 were retrospectively analyzed.The patients were divided into MODS group(n=36)and non-MODS group(n=163).The risk factors for tsutsugamushi disease combined with MODS were analyzed by univariate and multivariate logistic regression analysis.Results:There were signifi-cant differences in the age febrile time,leukocyte count and C-reactive protein(CRP)level between the two groups(P<0.05).Multivariate logistic regression analysis revealed that febrile time and CRP level were the risk factors for tsutsugamushi disease combined with MODS(P<0.05).Conclusion:Longer febrile time and higher CRP level were risk factors for tsutsugamushi disease combined with MODS.