托特罗定联合雌激素治疗成年女性膀胱过度活动症对患者自由尿流率的影响

The effect of tolterodine combined with estrogen in free urine flow rate in the treatment of adult female patients with overactive bladder

目的探讨托特罗定联合雌激素治疗成年女性膀胱过度活动症(OAB)对患者自由尿流率的影响。方法选择2012年9月~2014年9月在承德医学院附属医院泌尿外科、肾脏内科和妇科以尿频、尿急就诊的女性OAB患者144例作为研究对象,根据随机信封抽签原则分为对照组与观察组,每组各72例。对照组给予雌激素治疗,观察组在对照组治疗的基础上给予托特罗定治疗,两组均治疗3个月。比较两组治疗后临床疗效、不良反应、自由尿流率、夜间排尿次数及尿急次数。结果治疗后观察组总有效率(98.6%)高于对照组(84.7%),差异有统计学意义(P<0.05)。治疗前两组自由尿流率、夜间排尿次数与尿急次数比较,差异均无统计学意义(P>0.05);治疗后两组自由尿流率均高于治疗前,夜间排尿次数与尿急次数均低于治疗前,且治疗后观察组上述指标改善更加显著,差异均有统计学意义(均P<0.05)。治疗期间观察组口干、便秘等不良反应发生率均低于对照组,但差异无统计学意义(P>0.05)。结论托特罗定联合雌激素治疗成年女性OAB能提高患者的自由尿流率,改善临床症状,提高治疗效果,且有很好的安全性,值得临床推广应用。

Objective To investigate the free urine flow rate of tolterodine combined with estrogen in the treatment of adult female patients with overactive bladder(OAB).Methods From September 2012 to September 2014,144 cases of OAB patients with frequent micturition and urgency treated in the Department of Urology,Nephrology and Gynecology of Affiliated Hospital of Chengde Medical College were selected as the research object and divided into the observation group and the control group accorded to the random draw envelope principle,with 72 cases in each group.The control group was given estrogen therapy,while the observation group was given tolterodine combined with estrogen.Both groups were treated for 3 months.The therapeutic effects,adverse reactions,the free urine flow rate,frequency of urination and urgency at night between the two groups were compared.Results After treatment,the total effective rate in the observation group(98.6%)was higher than that of control group(84.7%),with statistically significant difference(P<0.05).Before treatment,there were no statistically significant differences between the two groups in the free urine flow rate,frequency of urination and urgency at night(P>0.05).After treatment,the free urine flow rate in both groups were all higher than those of before treatment,the symptoms of frequency of urination and urgency at night in both groups were lower than those of before treatment,and the indicators above in the observation group improved much more remarkably,with statistically significant differences(all P<0.05).During the treatment,the incidence of adverse reactions such as dry mouth and constipation in the observation group were lower than those of control group,but with no significant differences(P>0.05).Conclusion Tolterodine combined with estrogen in the treatment of adult female patients with OAB can increase the free urine flow rate,improve the clinical symptoms,promote the curative effect and has good security.It is worthy of clinical promotion and application.