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辛伐他汀的合成工艺改进 被引量:2

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摘要 辛伐他汀作为一种畅销的降血脂药物,在临床使用中因能有效降低冠心病的发病率和死亡率,已经是个成熟的降血脂类药物。在实际生产中对于辛伐他汀的合成重点是开环羟基保护,甲基化的控制与环合工艺质量收率的提高。本文主要对辛伐他汀合成路线进行比较,对羟基保护工艺与环合工艺进行研究改进。
作者 贺兆华
出处 《化工管理》 2018年第11期176-177,共2页 Chemical Engineering Management
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