探讨舒芬太尼在停用瑞芬太尼后早期疼痛中的预防效果

The Preventive Effect of Sufentanil on Early Pain After the Withdrawal of Remifentanil

目的探讨舒芬太尼在停用瑞芬太尼后早期疼痛中的预防效果。方法选择2017年1—12月我院收治的胆囊结石和(或)胆囊炎患者80例,按照随机数字法分为两组,各40例。观察组在手术结束前15min停用瑞芬太尼,并静脉给予舒芬太尼5~10μg,对照组则在手术结束后停用瑞芬太尼。对所有患者入组时相关情况进行统计,比较术后2 h内不同观察点疼痛VAS评分变化,统计术后24 h及48 h两组PCIA按压总次数。结果观察组拔管后即刻、拔管后10 min、拔管后30 min及拔管后2 h,观察组疼痛VAS评分均低于对照组(P<0.05),术后24 h及48 h,观察组PCIA按压次数少于对照组(P<0.05)。结论舒芬太尼能有效的预术后停用瑞芬太尼导致的爆发痛(痛觉过敏),从而更有效的提高麻醉安全性。

Objective To investigate the preventive effect of sufentanil on early pain after withdrawal of remifentanil.Methods 80 patients with cholecystolithiasis and/or cholecystitis admitted from January 2017 to December 2017 in our hospital were divided into two groups(n=40)according to the random number method.In the observation group,remifentanil was stopped 15 minutes before the end of surgery and 5~10μg of sufentanil was given intravenously.In the control group,remifentanil was stopped after the end of surgery.All patients were enrolled in the statistics related to the situation,2 h postoperative pain VAS score changes in different points,24 h and 48 h after surgery,the total number of PCIA compression in two groups were compared.Results The VAS score of the observation group immediately after extubation,10 min after extubation,30 min after extubation and 2 h after extubation were significantly lower than in the control group(P<0.05).At 24 and 48 h after operation,the number of times was significantly less than that of the control group(P<0.05).Conclusion Sufentanil can effectively prevent the outbreak of pain(hyperalgesia)caused by remifentanil after preoperative and postoperatively,so as to improve the safety of anesthesia more effectively.