气相色谱法测定氯乙酸乙酯的含量

Determination of Ethyl Chloroacetate by Gas Chromatography

用OV-1701毛细管色谱柱和氢火焰离子化检测器,以邻二甲苯为内标物,测定合成医药、农药及香料的重要中间体氯乙酸乙酯的含量。确立了色谱分析最佳条件为:进样口温度:200℃;FID检测器温度:200℃;柱温:恒温100℃。结果表明,此方法线性较好,相关系数为0.9999,标准偏差为0.15~0.84,变异系数为0.24%~1.04%,平均加标回收率为100.32%。实验证明本方法操作简单、快速、稳定性和重复性都较好。

A method for quantitative analysis of ethyl chloroacetate was described by gas chromatography with OV-1701 capillary column,FID detector and o-xylene as internal standard.The optimum chromatographic conditions were determined.Injection temperature was 200℃.FID detector temperature was 200℃.Column temperature was at a constant temperature of 100℃.The results showed that the linear correlation coefficient of the method was 0.9999.The standard deviations were found in the range of 0.15 and 0.84 with the coefficients of variation were between 0.24%and 1.04%.The average recovery was 100.32%.The experimental results showed that the method was simple,rapid,Stable and reliable.