探讨小儿肺炎支原体感染与免疫功能变化的关系

To explore the relationship between mycoplasma pneumoniae infection and immune function changes in children

目的探讨小儿肺炎支原体感染后免疫功能变化规律及临床意义。方法选取小儿肺炎支原体感染患者83例设为观察组,另选取同期在本院进行健康体检的小儿80例设为对照组,比较两组研究对象体液免疫指标、红细胞免疫指标、T淋巴细胞亚群水平。结果 (1)体液免疫:观察组血清免疫球蛋白IgG、IgM、IgA及补体C3、C4水平明显低于对照组,差异具有统计学意义(P<0.05);(2)红细胞免疫:观察组免疫复合物花环率、C3b受体花环率、免疫黏附促进因子低于对照组,免疫黏附抑制因子高于对照组,差异具有统计学意义(P<0.05);(3)T淋巴细胞亚群:观察组CD3^+、CD4^+、CD4^+/CD8^+低于对照组,CD8^+高于对照组,差异具有统计学意义(P<0.05)。结论小儿肺炎支原体感染后免疫功能处于低下状态,及时有效调节免疫功能对促进疾病恢复具有积极作用。

Objective To investigate the changes of immune function and its clinical significance in children with mycoplasma pneumoniae infection.Methods 83 cases of Mycoplasma pneumoniae infection were enrolled in this study from January 2015 to March 2017.Eight patients with healthy physical examination in our hospital were selected as the control group,and the two groups Pediatric humoral immune index,erythrocyte immune index,T lymphocyte subsets level.Results①Humoral immunity:The levels of serum immunoglobulin IgG,IgM,IgA and complement C3 and C4 in the observation group were significantly lower than those in the control group,The difference was statistically significant(P<0.05);②Erythrocyte immunization:The rosette rate,C3b receptor rosette rate and immune adhesion promoting factor were lower in the observation group than in the control group,the difference was statistically significant(P<0.05).③T lymphocyte subsets:CD3+,CD4+/CD8+were lower in the observation group than in the control group,the difference was statistically significant(P<0.05).Conclusion Mycoplasma pneumoniae infection in children with low immune function,timely and effective regulation of immune function to promote disease recovery has a positive effect.