小儿鼾症手术前后血浆生物标志物的变化及临床意义

Changes of plasma biomarkers in children with snoring before and after operation and their clinical significance

目的探析小儿鼾症手术前后血浆生物标志物的变化情况,以及研究血浆生物标志物的意义。方法选取2016年5月~2017年8月和平县人民医院耳鼻喉科收治的30例小儿鼾症患儿为主要研究对象,所有患儿均接受扁桃体/腺样体切除手术。对患儿手术前、手术后的血浆生物标志物进行测定,并对手术前后的变化情况进行对比分析。结果术后3个月,患儿的血浆hs-CRP、TNF-α、IL-6均明显低于手术前,数据差异有统计学意义(P<0.05)。结论血浆生物标志物与心血管疾病发病有一定相关性,对小儿鼾症患儿实施扁桃体/腺样体切除手术,可将鼾症患儿发生发展为动脉粥样硬化等心血管疾病的可能性降至最低,临床治疗有效率高,值得进一步推广和应用。

Objective To explore the changes of plasma biomarkers in children with snoring before and after operation,and the significance of studying plasma biomarkers.Methods From May 2016 to August 2017,30 children with snoring were selected from otolaryngology department of Heping County people's Hospital as the main subjects.All the children were underwent tonsillectomy/adenoidectomy.Results Three months after operation,the plasma hs-CRP,TNF-α,IL-6 levels were significantly lower than those before operation(P<0.05).Conclusion Plasma biomarkers were associated with cardiovascular diseases.Tonsillectomy in children with snoring could minimize the risk of developing into cardiovascular diseases such as atherosclerosis.The effective rate of clinical treatment is high,which is worthy of further popularization and application.