不同方案丙种球蛋白治疗儿童吉兰-巴雷综合征的疗效

Clinical efficacy of different schemes of IVIG in treating Guillain-Barrésyndrome in children

目的研究不同丙种球蛋白使用方案治疗儿童吉兰-巴雷综合征的疗效。方法收集2010年1月-2017年4月重庆医科大学附属儿童医院收治的136例吉兰-巴雷综合征患儿的临床资料,以不同丙种球蛋白使用方案分组(2组丙种球蛋白总量均为2g/kg,甲组分1~2d静脉滴注,乙组分3~5d静脉滴注),对治疗5d后、出院时、远期疗效及复发情况进行统计学分析。结果 2组患儿出院时疗效差异有统计学意义(P=0.02),甲组显效率为62.6%,乙组显效率为86.2%;2组患儿治疗5d后疗效、远期疗效及复发情况的比较差异无统计学意义(P>0.05)。结论丙种球蛋白总量2g/kg治疗儿童吉兰-巴雷综合征,分3~5d静脉滴注比分1~2d静脉滴注疗效好。

Objective To investigate the clinical efficacy of different schemes of intravenous immunoglobulin in treating children with Guillain-Barrésyndrome(GBS).Methods We collected the clinical data of 136 GBS children admitted by Children s Hospital of Chongqing Medical University between January 2010 and April 2017,and divided them into two groups according to the schemes of intravenous immunoglobulin(the total dose in the two groups was 2 g/kg):group 1 received intravenous drip for 1-2 days and group 2 intravenous drip for 3-5 days.The two groups were compared in curative effect after 5 days of treatment,at discharge,long term and relapse.Results The two groups differed significantly in clinical effect at discharge(P=0.02).The significantly effective rate in 1-2 days group and 3-5 days group was 62.6%and 86.2%,respectively.There was no significant difference in clinical effect after 5 days of treatment,long-term curative effect,or the relapse between the two groups(P>0.05).Conclusion The curative effect of total dose of 2 g/kg IVIG divided into 3-5 days intravenous drip in treating GBS in children was better than that of 1-2 days intravenous drip.