摘要
有机化合物绝对构型的测定在有机合成和药物合成方面都有着举足轻重的地位.Mosher法就是利用核磁共振波谱技术来确定复杂化合物绝对构型时所采用的一种巧妙方法.本研究即采用改良的Mosher法对无水鞘氨醇类天然产物pachastrissamine及其异构体全合成过程中的重要中间体高烯丙醇进行了绝对构型的测定.
Determination of the absolute configuration of organic compounds in organic synthesis and drug synthesis has a pivotal position.Mosher s method provides a practical solution for the stereoche-mistry determination of complex products by means of NMR spectroscopy.In this study,the modified Mosher s method was used to determine the absolute configuration of homoallylic alcohols as the important intermediates for the synthesis of pachastrissamine and its isoforms.
作者
杨皓然
杨新美
刘爱芹
TOMOYA Fujiwara
姚庆强
刘波
YANG Haoran;YANG Xinmei;LIU Aiqin;TOMOYA Fujiwara;YAO Qingqiang;LIU Bo(hool of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan 250200,Shandong,China;Institute of Materia Medica,Shandong Academy of Medical Sciences,Key Laboratory for Biotech-Drugs Ministry of Health, Key Laboratory of Rare and Uncommon Diseases of Shandong Province,Jinan 250062,Shandong,China;Department of Pharmacy,Shandong Provincial Qianfoshan hospital,Jinan 250014,Shandong,China;Graduate School of Medicine and Pharmaceutical Sciences,University of Toyama,Sugitani,Toyama 930-0194,Japan)
出处
《化学研究》
CAS
2018年第2期152-159,共8页
Chemical Research
基金
山东省自然科学基金(ZR2017PH003)
山东省医学科学院院级科技计划(2016-5)
关键词
Mosher法
高烯丙醇
绝对构型
结构测定
Mosher s method
homollylic alcohols
absolute configuration
structural determination
