肿瘤血管生成机制及抗肿瘤血管新生的靶向药物研究进展

Tumor angiogenesis and tumor vascular-targeted drug: research advances

抗肿瘤血管新生治疗是以血管内皮细胞为靶点,通过降低血管活性因子的活性、抑制内皮细胞增殖和迁移、改变肿瘤生长微环境,从而抑制肿瘤生长过程中的血管新生,切断肿瘤的供养,最终达到遏制肿瘤生长和转移的目的,是一种全新的靶向肿瘤治疗方法。该方法具有高效特异性、不易产生耐药性、药物易于到达靶部位和毒副作用小等优点,可以有效地抑制肿瘤的转移和复发,现在已成为抗肿瘤血管生成药物研究的热点之一,该文综述了肿瘤血管生成的机制及抗血管新生治疗药物的最新研究进展。

Anti-angiogenesis therapy targeting vascular endothelial cells is a new promising method,which could reduce the activity of vasoactive factors and inhibit proliferation and migration of endothelial cell,as well as improve the tumor growth microenvironment.The anti-angiogenesis therapy could ultimately curb tumor growth and metastasis by inhibiting neovascularization during tumor growth and cutting off the tumor′s nutritional supply.The method has the advantages of high specificity,resistance to drug resistance,easy access to the target site and low toxic side effects,and can effectively inhibit tumor metastasis and recurrence.It has become one of the hot spots of anti-tumor drug research.In this review,we review the mechanisms of tumor angiogenesis and the latest advances in anti-angiogenesis drugs.