多磺酸黏多糖乳膏联合曲安奈德益康唑乳膏治疗成人慢性湿疹45例

Clinical efficacy of mucopolysaccharide polysulfate cream combined with triamcinolone acetonide and econazole cream in the treatment of adult with chronic eczema

目的观察多磺酸黏多糖乳膏与曲安奈德益康唑乳膏联合应用治疗成人慢性湿疹的临床效果。方法选取90例成人慢性湿疹患者作为研究对象,采用随机数字表法分为两组,每组45例,其中对照组采用曲安奈德益康唑乳膏治疗,观察组在对照组治疗的基础上,联合多磺酸黏多糖乳膏治疗,观察并比较两组患者经过用药后的临床效果及随访恢复情况。结果观察组总有效率(91.11%)明显高于对照组(60.00%),差异有统计学意义(P<0.05);观察组患者临床各指标积分(4.81±1.01)分明显优于对照组(10.61±2.60)分,差异有统计学意义(P<0.05);观察组患者透明质酸酶合成的增长率(639.15±140.43)%明显高于对照组(48.98±14.26)%,差异有统计学意义(P<0.05);治疗后,观察组患者皮肤水份情况(46.15±14.32)%明显优于对照组(40.02±11.56)%,差异有统计学意义(P<0.05)。结论在曲安奈德益康唑乳膏治疗的基础上,联合多磺酸黏多糖乳膏对成人慢性湿疹的治疗具有积极作用,提高临床总有效率,有效改善自觉瘙痒程度、皮损厚度和皮肤软硬度及颜色恢复等方面的临床状况,患者皮肤水份得以维持,为受损皮肤的组织再生提供了保障,值得临床广泛应用。

Objective To analyze the clinical effect of Mucopolysaccharide polysulfate cream combined with Triamcinolone acetonide and econazole cream in the treatment of adult with chronic eczema.Methods Ninety adult patients with chronic eczema were randomly assigned into two groups,with 45 cases in each group.The control group was treated with Triamcinolone acetonide and econazole cream while the observation group was given Triamcinolone acetonide and econazole cream and Mucopolysaccharide polysulfate cream.The clinical efficacy after drug treatment and follow-up of the two groups were compared.Results The overall efficiency of the observation group(91.11%)was significantly higher than that in the control group(60.00%),with statistical significance(P<0.05).The scores of clinical indexes in the observation group(4.81±1.01)points were significantly better than those in the control group(1.061±2.60)points,with statistical significance(P<0.05).The growth rate of hyaluronic acid enzyme synthesis in the observation group(639.15±14.043)%was significantly higher than that in the control group(48.98±14.26)%,the difference was significant(P<0.05).After the treatment,the skin moisture of the observation group(46.15±14.32)%was significantly better than the control group(40.02±11.56)%,the difference was significant(P<0.05).Conclusions The combined treatment of Mucopolysaccharide polysulfate cream+Triamcinolone acetonide and econazole cream has positive effect on the treatment of adult with chronic eczema,increases clinical total efficiency,improves the degree of consciously itching,skin thickness and hardness,as well as color restoration,maintains patient skin moisture,provides a guarantee for the regeneration of damaged skin,and it should be widely used in clinic.