卵巢癌转移相关基因异常表达的相关性研究

Correlation study of abnormal expression of metastatic genes in ovarian cancer

目的进行卵巢癌(OC)转移相关基因异常表达的相关性研究。方法对NCBI中GEO数据库中的若干数据集数据进行表达量分析、生存分析和相关性分析。结果研究分析表明,Snai1和Twist1等OC转移相关基因在OC患者中存在明显的高表达。Snai1和Twist1等的高表达会导致OC患者的总生存率和无疾病生存率明显降低(Snai1,P<0.05;Twist1,P<0.05)。Snai1和Twist1在药物治疗后的OC患者中有明显的高表达情况(Snai1,P<0.05;Twist1,P<0.05)。Snai1和Twist1在OC患者中的表达情况呈正相关(r=0.452,P<0.01)。结论 OC转移相关基因的异常表达与OC患者疾病的发展存在相关性,并且对其药物耐受和预后都有影响。

Objective Based on relevant database data analysis,to explore the correlation of the abnormal expression of ovarian cancer-related gene and ovarian cancer.Methods Based on some data sets of GEO in the NCBI database,to perform express analysis,survival analysis and correlation analysis.Results The results showed that Snail1 and Twist1 in ovarian cancer patients significantly higher expressed.The high expression of Snai1 and Twist1 could lead to a significant reduction in overall survival and disease-free survival in ovarian cancer patients(Snai1,P<0.05,Twist1,P<0.05).Snai1 and Twist1 had significant high expression in ovarian cancer after drug therapy(Snai1,P<0.05,Twist1,P<0.05).Snai1 and Twist1 positively correlated in ovarian cancer(r=0.452,P<0.01).Conclusion The abnormal expression of ovarian cancer metastasis-related genes associated with the development of ovarian cancer patients and had effection on their drug tolerance and prognosis.