成都地区妇女宫颈人乳头状瘤病毒HPV52/58感染状况调查

Investigation of human papillomavirus HPV52/58 infection in women in Chengdu area

目的了解成都地区女性宫颈脱落细胞人乳头状瘤病毒(HPV)52/58感染情况并提供流行病学依据。方法采集该地区女性宫颈脱落细胞,采用HPV基因分型方法检测HPV52/58感染率、年龄特征、感染模式。结果 HPV52/58是该地区HPV高危型感染前3位的基因型,HPV52、HPV58感染率分别为4.91%和2.46%,HPV52/58感染率在不同年龄组差异有统计学意义(P<0.05),具有两个感染高峰年龄段是<20岁和≥60岁;HPV52和HPV58单一感染高发年龄段分别为30～<50岁和30～<60岁,HPV 52-高危型混合感染率在≥60岁最高(均P<0.05),HPV58低危型混合感染率在<20岁高于其他年龄(均P<0.05),HPV52最常与16、58、81、53、51构成多重感染,HPV58最常与52、16、81、53、51构成多重感染。结论我国疫苗的覆盖类型有必要考虑到HPV52/58,加强高危年龄段女性宫颈癌筛查及预防性HPV52/58疫苗使用,有效降低HPV感染率。

Objective To investigate the prevalence of human papillomavirus HPV52/58 infection in female cervical exfoliated cells in Chengdu area,and to provide epidemiological evidence for HPV52/58 infection.Methods The female cervical exfoliated cells were collected in Chengdu area.The HPV52/58 infection rate,age characteristics and infection patterns were detected by HPV genotyping.Results HPV52/58 is in the top three in Chengdu,HPV52,HPV58 infection rates were 4.91%and 2.46%,the infection rate of HPV52/58 was statistically significant difference in different age group(P<0.05),HPV52/58 had two infection peak age which were under 20 years and more or equal to 60 years old,HPV52 and HPV58 single infection age were 30-<50 and 30-<60 years old,HPV 52-high-risk mixed infection rate was the highest in more or equal to 60 years old(P<0.05),low risk HPV58-mixed infection rate in less than 20 years old was higher than that of other age(P<0.05),HPV52 was the most common with 16,58,81,53,51 the combination of multiple infections,HPV58 was most common with 52,16,81,53,51 combined into multiple infections.Conclusion In our country,it is necessary to take into account the HPV52/58 vaccine,to strengthen the high-risk age women cervical carcinoma screening and the use of HPV52/58 vaccine in order to effectively reduce the rate of HPV infection.