点阵激光联合氟米松治疗慢性湿疹的临床疗效观察

Clinical Observation on the Treatment of Chronic Eczema with Dot Matrix Laser and Flumethasone

目的:探讨点阵激光联合氟米松治疗慢性湿疹的临床疗效。方法:收集2016年7月至2017年9月门诊治疗的100例慢性湿疹患者随机分为两组,单药组患者给予氟米松,联合组患者则加用点阵激光治疗,比较两组患者VAS评分、EASI评分、总体治疗效果、细胞因子与生活质量。结果:联合组患者治疗后VAS评分与EASI评分组间比较均显著性低于单药组;显效率与总有效率均显著性高于单药组;治疗后IL-2、IL-4、IL-10、Ig E与LTB4水平组间比较均显著性低于单药组,IFN-γ水平显著性高于单药组;治疗后EPQOLS总分组间比较显著性低于单药组,存在显著性差异(P<0.05)。结论:点阵激光联合氟米松治疗慢性湿疹的临床疗效显著,具有借鉴意义。

Objective:To investigate the clinical efficacy of dot-matrix laser combined with flumethasone in the treatment of chronic eczema.Methods:100 patients with chronic eczema who were treated in outpatient department from July 2016 to September 2017 were randomly divided into two groups.Patients in the single drug group were treated with flumethasone,while patients in the combined group were treated with laser dextrose injection.VAS score was compared between the two groups,EASI score,overall treatment effect,cytokines and quality of life.Results:After treatment,the VAS score and EASI score in the combined group were significantly lower than those in the single drug group.The effective rate and total effective rate were significantly higher in the combination group than those in the single drug group.The levels of IL-2,IL-4,IL-10,IgE and LTB4 levels were significantly lower than the single drug group,IFN-γlevels were significantly higher than the single drug group;after treatment EPQOLS total score was significantly lower than the single drug group,there was a significant difference(P<0.05).Conclusion:The clinical efficacy of dot-matrix laser combined with flumethasone in the treatment of chronic eczema is significant and has reference value.