维生素D水平与卵巢癌患者生存状态的关系研究

The Relationship between Vitamin D Levels and the Survival Status of Patients with Ovarian Cancer

目的:探讨维生素D水平与卵巢癌患者生存状态的关系。方法:纳入2009年8月至2011年1月期间收治的168例卵巢癌患者,随访5年,利用Log rank检验和方差分析等比较不同血清25(OH)D水平患者的无进展生存期(率)、5年总生存期(率)和Karnofsky评分。结果:不同血清25(OH)D水平患者的中位无进展生存期和5年无进展生存率比较差异无统计学意义(χ2=2.298,logrank P=0.513);而不同血清25(OH)D水平患者的中位生存期和5年总生存率比较差异有统计学意义(χ2=12.342,log-rank P=0.006),25(OH)D为25.0～49.9 nmo L/L水平患者的中位生存期最高,50.0～74.9 nmo L/L者5年总生存率最高;不同血清25(OH)D水平患者的Karnofsky评分差异无统计学意义(P均>0.05)。结论:维生素D水平与卵巢癌患者的5年总生存率相关,血清25(OH)D浓度为25.0～74.9nmo L/L者生存状态更好。

Objective:To explore the relationship between vitamin D levels and the survival status of patients with ovarian cancer.Method:Total 168 patients with ovarian cancer were included during August 2009 to January 2011,then 5 years follow up was conducted,Log rank test and variance analysis were used to compare the progression free survival(rate),5-year overall survival(rate),and Karnofsky score among patients with different serum 25(OH)D levels.Results:The median progression-free survival and 5-year progression-free survival were not significantly difference among patients with different serum 25(OH)D levels(χ2=2.298,log-rank P=0.513);the median overall survival and 5-year overall survival were significantly difference among patients with different serum 25(OH)D levels(χ2=12.342,log-rank P=0.006),and patients with serum levels of 25.0~49.9 nmoL/L had longest median overall survival,while 50.0~74.9 nmoL/L had highest overall survival rate;Karnofsky scores was also no significantly difference among patients with different serum 25(OH)D levels(P>0.05).Conclusion:The vitamin D levels are associated with the 5 year total survival rate in patients with ovarian cancer,and the survival status of 25.0~74.9 nmoL/L in serum 25(OH)D was better.