抑郁症功能磁共振成像脑网络研究进展

Progress in the study of functional magnetic resonance imaging(fMRI) brain networks in the depression

近年来,功能磁共振成像技术的发展使得研究者可以无创地研究活体脑组织结构和功能特点,结合多种脑成像技术研究大尺度的脑结构和功能网络,为研究某些疾病的发生和发展机制提供了可靠的方法。目前抑郁症患者的磁共振脑网络研究还处在初步探索阶段,脑网络的拓扑属性在某种程度上对抑郁症患者的早期诊断和鉴别诊断起到一定的辅助作用,同时也可以作为一个衡量抑郁症严重程度的生理指标。脑结构和功能的异常模式也可作为敏感特征用于诊断相关脑疾病,因此本文将从抑郁症层面综述几个主要的磁共振脑网络的结构和功能方面的研究成果。

In recent years,the development of functional magnetic resonance imaging technology has enabled researchers to study the structure and function of living brain tissue without invasive research,and the study of large scale brain structure and function network is necessary to study the occurrence and development mechanism of certain diseases.Currently,the study of brain network in patients with depression is still in the preliminary stage of exploration,the topological properties of brain network play an auxiliary role in early diagnosis and differential diagnosis of depressed patients,it can also be used as a measure of the severity of depression.Abnormal patterns of brain structure and function can also be used as sensitive features to diagnose related brain diseases,therefore,this paper will review the research results of brain structure and function of depressed patients from the perspective of brain network.