冠状动脉微栓塞动物模型磁共振成像研究及其进展

Research and progress of magnetic resonance imaging on coronary microembolization using animal models

冠状动脉微栓塞(coronary microembolization,CME)常见于急性冠脉综合症和经皮冠状动脉治疗术(percutaneous coronary intervention,PCI)过程中,危害很大。近年来,国内接受PCI的患者数量大幅增长,由此引起的CME病变也越来越常见。与其他影像学检查方法相比,MRI具有无创、无电离辐射、软组织分辨率高等优势,并可"一站式"检查获取心脏解剖和功能信息,常被用于评估微栓塞后心肌功能和灌注异常、进行心肌活性成像,在冠状动脉微栓塞病变的研究中起着重要作用。CME动物模型常被用于深入研究微栓塞病变的病理生理改变、心肌损伤机制,本文主要概述MRI在CME动物模型方面的研究及其进展。

Coronary microembolization(CME)occurs frequently in acute coronary syndrome and the process of percutaneous coronary intervention(PCI),which is very harmful for patients.In recent years,the number of patients receiving PCI in China has increased significantly,and the coronary microembolization after PCI also becomes more common than ever.Compared with other methods,magnetic resonance imaging(MRI)is a noninvasive method without ionizing radiation and has the advantages of high soft tissue resolution and"one-stop"inspection with cardiac anatomy and function information.MRI plays an important role in the study on coronary microembolization and can be used to assess myocardial function,perfusion abnormalities and myocardial activity related to coronary microembolization.Animal models of coronary microembolization were commonly used in-depth study on pathophysiology of CME and mechanism of relevant myocardial injury.This review focused on research and progress in MRI on coronary microembolization of animal models.