乌司他丁辅助连续性血液净化对重症脓毒血症的疗效分析

Analysis on the efficacy of ulinastatin in the treatment of severe sepsis by continuous blood purification

目的:探究重症脓毒血症治疗中应用乌司他丁辅助连续性血液净化的效果。方法:收治重症脓毒血症患者80例,单一组(35例)使用连续性血液净化治疗,联合组(45例)使用乌司他丁辅助连续性血液净化治疗。结果:联合组存活率远高于单一组(P<0.05);治疗后TNF-α、IL-6、IL-8均有所降低(P<0.05),联合组远低于单一组(P<0.05);治疗后患者APACHEⅡ评分均有所降低(P<0.05),联合组远低于单一组(P<0.05)。结论:重症脓毒血症治疗中应用乌司他丁辅助连续性血液净化可降低患者炎性因子水平、改善患者病情、提升存活率。

Objective:To explore the effect of ulinastatin in the treatment of continuous blood purification on severe sepsis.Methods:A total of 80 patients with severe sepsis were selected,the single group(with 35 cases)were treated with continuous blood purification,while the combined group(with 45 cases)were treated with Ulinastatin to assist the continuous blood purification.Results:The survival rate of the combined group was much higher than that of the single group(P<0.05);TNF-,IL-8 alpha and IL-6 were decreased after the treatment(P<0.05),and the combined group is much lower than the single group(P<0.05);patients with APACHE score were decreased after the treatment(P<0.05),in the combined group far lower than in the single group(P<0.05).Conclusion:Application of ulinastatin and continuous blood purification in the treatment of severe sepsis can reduce the level of inflammatory factors,improve the patients'condition and improve the survival rate.