丙泊酚静脉麻醉在急性重型颅脑损伤术中的脑保护价值探讨

Discussion on the value of propofol intravenous anesthesia in the operation of acute severe craniocerebral injury

目的:探讨丙泊酚麻醉在急性重型颅脑损伤术中的脑保护价值。方法:收治急性重型颅脑手术的患者100例,随机平分两组。观察组采用丙泊酚静脉麻醉,对照组采用咪达唑仑诱导与维持麻醉,比较两组患者的治疗结果。结果:术中和术毕,观察组的PbrO_2水平均比对照组高,差异有统计学意义(P<0.05);两组患者在术毕和术后1h的Glu、MDA、SOD水平比较,差异有统计学意义(P<0.05)。结论:丙泊酚静脉麻醉在急性重型颅脑损伤手术中,能降低患者颅内压,提高脑氧分压,保护神经组织。

Objective:To explore the value of propofol anesthesia in the operation of acute severe craniocerebral injury.Methods:100 patients with acute severe craniocerebral injury were selected,they were randomly divided into the two groups on average,the observation group used intravenous anesthesia with propofol,the control group used midazolam induction and maintenance of anesthesia,we compared the results of the two groups of patients.Results:The levels of PbrO2 in the observation group were higher than those in the control group at the end of surgery and during surgery,the difference was statistically significant(P<0.05).There was significant difference in Glu,MDA and SOD levels between the two groups at the end of surgery and at 1 hour after surgery(P<0.05).Conclusion:In the operation of acute severe craniocerebral injury,intravenous anesthesia of propofol can reduce the intracranial pressure,increase the partial pressure of brain oxygen and protect the nerve tissue.