吡格列酮和胰岛素治疗2型糖尿病患者的临床效果观察

Clinical effect of pioglitazone and insulin in the treatment of patients with type 2 diabetes

目的:探讨吡格列酮和胰岛素治疗2型糖尿病的效果。方法:收治2型糖尿病患者112例,随机分为常规组与研究组,各56例。常规组单纯用胰岛素治疗,研究组在此基础之上联合吡格列酮。结果:研究组空腹血糖、餐后2 h血糖水平、糖化血红蛋白以及胰岛素用量显著低于常规组(P<0.05)。结论:吡格列酮联合胰岛素治疗2型糖尿,可获得满意疗效,有利于患者血糖控制,减少每天胰岛素用量,且不良反应少,安全性高。

Objective:To investigate the effect of pioglitazone and insulin in the treatment of type 2 diabetes.Methods:112 patients with type 2 diabetes were randomly divided into the routine group and the study group,with 56 cases in each group.The routine group was treated with insulin alone,and the study group combined with pioglitazone on the basis of insulin.Results:The fasting blood glucose,2h postprandial blood glucose level,glycated hemoglobin and insulin dosage in the study group were significantly lower than that of the conventional group(P<0.05).Conclusion:Pioglitazone combined with insulin in the treatment of type 2 diabetes can achieve satisfactory results,which is conducive to blood glucose control and daily dosage of insulin,and has fewer adverse reactions and high safety.