维他命E联合葡萄糖酸钙及阿司匹林对重度子痫前期患者干预效果研究

Effect of Aspirin,Calcium gluconate and Vitamin E on severe preeclampsia

目的:探讨重度子痫前期患者接受阿司匹林、葡萄糖酸钙、维他命E联合干预效果。方法:对照组重度子痫前期患者给予硫酸镁+拉贝洛尔的临床常规治疗,研究组重度子痫前期患者在常规治疗基础上加用阿司匹林、葡萄糖酸钙、维他命E,记录两组治疗前、后舒张压、收缩压变化情况及母婴结局。结果:治疗前两组DBP、SBP检测值对比P>0.05,治疗后研究组DBP、SBP检测值较之前下降幅度优于对照组(P均<0.05);研究组剖宫产率(45.83%)显著低于对照组(79.17%)(P<0.05;对照组医源性早产、子痫、产后出血、胎儿窘迫等母婴不良反应发生率显著高于研究组(P均<0.05)。结论:应用维他命E、阿司匹林、葡萄糖酸钙可显著提高重度子痫前期患者临床疗效,对保障母婴安全具有积极意义。

Objective:To investigate the effect of the combined intervention of aspirin,calcium gluconate and vitamin E in patients with severe preeclampsia.Methods:The control group of patients with severe preeclampsia received the clinical routine treatment of Magnesium Sulfate combined with labetalol,the study group of patients with severe preeclampsia were treated with aspirin,calcium gluconate,vitamin E.Before and after treatment,the diastolic blood pressure and systolic blood pressure changes and outcomes of two groups were compared.Results:DBP,SBP detection value of two groups showed no statistical significant difference,P>0.05 before treatment;After treatment,the DBP,SBP detection value of the study group declined more significantly than that of the control group(P<0.05);the cesarean section rate of the study group(45.83%)was significantly lower than that of the control group(79.17%)(P<0.05);The adverse reaction of iatrogenic preterm delivery,child epilepsy,postpartum hemorrhage,fetal distress and other maternal and child diseases of the control group was significantly higher than that in study group(P<0.05).Conclusion:The combination of vitamin E,aspirin and calcium gluconate could significantly improve the clinical efficacy in treating severe preeclampsia,and it had positive significance for the safety of mother and infant.