中药治疗骨关节炎的短期临床疗效观察

Effective observation on treating osteoarthritis in TCM

目的:观察中药内服、中药熏蒸及西药外用治疗骨关节炎(OA)的短期疗效及安全性。方法:将150例OA患者随机分为三组,分别为中药内服组(A组)、中药熏蒸组(B组)和西药外用组(C组),每组50例,治疗6个月后观察治疗前后超声下滑膜厚度、软骨厚度的变化、检测外周血细胞因子IL-1β、IL-6、TNF-α以及观察WOMAC评分的变化。结果:治疗6个月后,中药内服、中药熏蒸及西药外用三组均明显降低IL-1β、IL-6、TNF-α水平、降低滑膜厚度及降低WOMAC评分(P<0.05),且A组在降低IL-1β、IL-6、TNF-α水平、降低滑膜厚度的疗效明显优于AB两组(P<0.05),治疗后三组关节软骨厚度未见明显变化(P>0.05),同时中药内服、中药熏蒸及西药外用三组未发生严重不良事件,安全性均较好。结论:中药在治疗骨关节炎中可有效控制滑膜炎症、减轻关节肿胀疼痛等症状、有效阻止关节软骨破坏,且不良反应少、安全性高。

Objective:To observe the short-term clinical effect and security of herbal oral administration,traditional Chinese medicine fumigation and vitalin emulgel for external use in the treatment of osteoarthritis.Methods:150 OA patients were randomly divided into three groups,with 50 cases in each group.The changes of the thickness of synovial and cartilage under the joint ultrasound,the WOMAC score and the level of the cytokines IL-1β,IL-6 and TNF-αin peripheral blood after 6 months of treatment were observed.Results:After 6 months of treatment,the thickness of synovial,the WOMAC score and the level of IL-1β,IL-6 and TNF-αof the 3 groups were all decreased significantly than those before treatment(P<0.05).The curative effect of group A was significantly better than that of the groups B and group C(P<0.05).But,the thickness of cartilage of three groups had no obvious change compared with that before treatment(P>0.05).Meanwhile,there was no serious adverse events and it had good security.Conclusion:Traditional Chinese medicine could effectively control the synovial inflammation in the treatment of osteoarthritis,relieve joint swelling and pain and other symptoms and prevent the destruction of articular cartilage effectively,it also had good safety and less adverse reaction.