血浆内毒素水平与慢性肾脏病及其营养状态的相关性研究

Relationship between plasmic endotoxin and chronic kidney diseases and the patients' nutritional status

目的探讨血浆内毒素水平与慢性肾脏病严重程度及患者营养状态的关系。方法选取80例慢性肾脏病患者,根据肌酐清除率分为非终末期肾病组及终末期肾病组,选取40例健康者作为正常对照组,检测受试者的血浆内毒素、血常规、血清肌酐、白蛋白及总胆固醇、甘油三酯水平,对比各组血浆内毒素水平差异,并对慢性肾脏病患者血浆内毒素水平与血红蛋白、血清白蛋白、总胆固醇、甘油三酯进行水平相关性分析。结果 (1)慢性肾脏病患者的血浆内毒素水平较正常对照组均明显升高,且组间两两比较差异均有统计学意义(P<0.05)。(2)慢性肾脏病各组血浆内毒素与血红蛋白、血白蛋白呈负相关,差异有统计学意义(P<0.05)。结论慢性肾脏病患者存在高内毒素血症,高内毒素水平可能是慢性肾脏病发生发展的影响因素,且可能与慢性肾脏病患者贫血及低蛋白血症相关。

Objective To explore the role of plasmic endotoxin in the development of chronic kidney diseases and the correlation between plasmic endotoxin and the CKD patients’nutritional status.Methods Plasmic endotoxin,hemoglobin,serum albumin,cholesterol total and triglyceride levels were measured and compared in a total of 40 patients with end stage renal diseases and 40 patients with eraly stage renal diseases and 40 healthy volunteers.Results⑴The patients with chronic kidney diseases had higher plasmic endotoxin levels than healthy subjects and the difference was significant(P<0.05).Significant differences were observed in pairwise comparison(P<0.05).⑵Plasmic endotoxin levels levels in CKD patients were negatively correlated with hemoglobin and serum albumin.Conclusion There were certain relationships between plasmic endotoxin and chronic kidney diseases.Endotoxin may play an important role in their procedures,the patients’anemia and hypoproteinemia.