儿童急性淋巴细胞白血病合并肺孢子菌肺炎预防治疗

Prophylactic treatment of Pneumocystis carinii pneumonia in children with acute leukemia

目的探讨儿童急性淋巴细胞白血病化疗后并发肺孢子菌肺炎的临床特征及预防治疗方法。方法通过分析268例儿童急性淋巴细胞白血病病例,分析合并肺孢子菌肺炎患者的临床特点及预防治疗效果。结果⑴肺孢子菌肺炎主要表现发热、咳嗽及呼吸困难,伴有低氧血症及乳酸脱氢酶增高。⑵未进行预防治疗的儿童急性淋巴细胞白血病患者肺孢子菌肺炎发病率高。结论口服复方磺胺甲噁唑能有效预防肺孢子菌肺炎,试验组与对照组预防治疗方法效果相似。

Objective To explore the clinical characteristics and prevention methods of Pneumocystis carinii pneumonia in children with acute lymphoblastic leukemia after chemotherapy.Methods Analysis of 268 cases of acute lymphoblastic leukemia in children,to study the clinical characteristics and prophylactic treatment effect of Pneumocystis carinii pneumonia.Results⑴Major clinical features of Pneumocystis carinii pneumonia was fever、cough、dyspnea、Hypoxemia and high lactate dehydrogenase.⑵The incidence of Pneumocystis carinii pneumonia in children with acute lymphoblastic leukemia without prophylactic treatment was high.Conclusion Oral trimethoprim-sulfamethoxazole can effectively prevent Pneumocystis carinii pneumonia.The prophylactic treatment effect of the treatment group and the control group was similar.