120例HPV感染孕产妇妊娠结局临床分析

Clinical analysis of pregnancy outcome of 120 HPV-infected pregnant women

目的调查分析人乳头瘤病毒(HPV)感染孕产妇的妊娠结局。方法选择医院收治的120例感染HPV的孕产妇为研究组,并以同期本院110例未感染HPV的孕产妇作为对照组,对两组的妊娠结局进行对比分析。结果研究组均未要求终止妊娠,经阴道分娩66例(55.00%),剖宫产分娩54例(45.00%),与对照组相比无差异(P>0.05)。研究组中,高危型HPV(HR-HPV)感染64例(53.33%),低危型HPV(LR-HPV)感染51例(42.50%),高低危型混合感染感染5例(4.17%),其中HRHPV感染和高低危型混合感染者的胎膜早破、产褥感染的发生率均显著高于对照组(P<0.05),但是LR-HPV感染者与对照组比较无显著差异(P>0.05)。两组早产、产后出血、胎儿窘迫等不良妊娠结局的发生率比较无显著差异(P>0.05)。研究组中,HRHPV和高低危型混合感染者新生儿HPV感染率均显著高于LR-HPV感染者新生儿(P<0.05),HR-HPV与高低危型混合感染者新生儿HPV感染率比较,差异无统计学意义(P>0.05)。结论 HR-HPV感染和高低危型混合感染会增加孕产妇胎膜早破、产褥感染的发病率,且导致母婴传播引起新生儿HPV感染的风险较高,因此,应加强对孕产妇HPV感染的早期筛查和积极干预。

Objective To research and analyze the pregnancy outcome of HPV-infected pregnant women^A total of 120 HPV-infected pregnant women admitted into our hospital were selected to constitute a research group and a total of 110 pregnant women admitted into our hospital without HPV infections were selected to constitute a control group.Comparative analysis was performed on the pregnancy outcomes of these women in the two groups.Results None of the pregnant women of the research group requested for termination of pregnancy,in which 66(55.00%)made vaginal delivery and 54(45.00%)made delivery by caesarean section,no difference from the control group>0.05).The research group contained 64(53.33%)high risk HPV(HR-HPV)infections,51(42.50%)low risk HPV(LR-HPV)infections and five(4.17%)HR-LR HPV infections.In particular,the patients of HR-HPV infection and HR-LR HPV infection showed higher incidence of premature rupture of membrane and puerperal infection(P<0.05),but no significant difference from the control group was found for LR-HPV patients(P>0.05).No significant differences were found in unfavorable pregnancy outcomes,such as premature delivery,postpartum hemorrhage and fetal distress between the groups(P>0.05).As to the research group,the HPV neonatal infection rates of HR-HPV and HR-LR HPV patients were significantly higher than those of the newborns of LR-HPV patients(P<0.05).No statistically significant difference was found in the comparison of neonatal infection rates between HR-HPV and HR-LR HPV patients(P>0.05).Conclusion HR-HPV infection and HR-LR HPV infection can cause higher incidence of premature rupture of membrane and puerperal infection of pregnant women as well as high risk of neonatal HPV infection due to mother-to-fetus transmission.As a result,it is essential to improve early screening and proactive intervention for HPV infection of pregnant women.