生物活性陶瓷、骨形态发生蛋白、医用生物蛋白胶复合物诱导成骨活性研究

Osteogenic activity induced by complex of bioactive glass ceramics,bone morphogenetic protein,and biomedical fibrin glue

目的通过实验对比研究,探讨陶瓷人工骨、骨形态发生蛋白及纤维蛋白复合物异位诱导成骨活性。方法选纯种SD大鼠20只,随机分为A、B、C 3组,组内分为2组,第1组陶瓷人工骨、骨形态发生蛋白及纤维蛋白复合物;第2组陶瓷人工骨。在第4周观察移植效果。结果陶瓷人工骨、骨形态发生蛋白及纤维蛋白复合物植入组植入有效率(70%对60%),组织生长有效率(60%对40%),组织碱性磷酸酶活性(0.441±0.082对0.234±0.022)均显著优于陶瓷人工骨组,组间比较差异显著(P<0.05)。结论陶瓷人工骨、骨形态发生蛋白及纤维蛋白复合物植入的方法对植入物的成骨有促进作用。

Objective To investigate the osteogenic activity induced by the complex of bioactive glass ceramics(BGC),bone morphogenetic protein(BMP),and biomedical fibrin glue(BFG).Methods Twenty SD rats were randomly divided into A,B,and C groups and each group as further divided into two subgroups.The complex of BGC,BMP,and BFG as used in subgroup 1,and ceramic artificial bone as used in subgroup 2.The transplantation effect was observed after 4 weeks.Results The implantation efficiency rate(70%vs.60%),tissue growth efficiency rate(60%vs.40%),and activity of alkaline phosphatase(0.441±0.082 vs.0.234±0.022)of the subgroup 1 were significantly higher than those of the subgroup 2(P<0.05).Conclusion The complex of BGC,BMP,and BFG could ossify implants.