阿帕替尼治疗晚期化疗耐药胃癌的临床效果分析

Clinical Effect of Apatinib in the Treatment of Advanced Chemotherapy Resistant Gastric Cancer

目的:分析研讨阿帕替尼治疗晚期化疗耐药胃癌的临床效果。方法:用1:1随机数字法分2组讨论我院2015年8月—2017年5月期间收治的晚期化疗耐药胃癌患者80例,每组40例,对照组接受常规化疗,研究组接受常规化疗+阿帕替尼,观察两组患者治疗效果、不良反应等,并比较。结果:研究组疾病总控制率92.50%高于对照组77.50%,且P<0.05。研究组不良反应总发生率15%低于对照组32.50%,且P<0.05。结论:建议治疗晚期化疗耐药胃癌疾病可考虑在常规化疗基础上给予阿帕替尼,其疗效突出,安全可靠,亦可作为首选治疗方式。

Objective:To analyze and discuss the clinical effect of apatinib in treatment of advanced chemotherapy resistant gastric cancer.Methods:80 cases of patients with advanced chemotherapy resistant gastric cancer and who treated in our hospital from August 2015 to May 2017 were divided into two groups by random number method,with 40 cases in each group.The control group was received routine chemotherapy,while the study group were received routine chemotherapy combined with apatinib.Then,the treatment of clinical effect,the adverse reaction and so on of two groups of patients were observed and compared.Results:The total control rate of disease in the study group was 92.50%,which was higher than that in the control group of 77.50%,and P<0.05.The total adverse reaction rate in the study group was 15%,which was lower than that in the control group of 32.50%,and P<0.05.Conclusion:It is suggested the treatment of advanced chemotherapy resistant gastric cancer which can be considered on the basis of routine chemotherapy given apatinib drugs,its clinical effect are prominent and safe and reliable,thus it can also be used as the preferred treatment.