摘要
1位62岁男性慢性肾功能衰竭尿毒症期患者,因泌尿系感染静脉滴注磺苄西林3g(1次/12h)。用药第6天,实验室检查示:TBil 3.9μmol/L,ALT 184.2U/L,AST 319.8U/L,γ-GT 79U/L,ALP 67.1U/L,考虑可能为药物性肝损伤,停用磺苄西林,余治疗不变。停用磺苄西林第7天复查,TBil 3.4μmol/L,ALT 64U/L,AST 27U/L。
A 62-year-old patient with chronic renal failure received intravenous sulbenicillin 3 g twice daily for urinary tract infection.On day 6,laboratory tests showed the following results:total bilirubin(TBil)3.9μmol/l,alanine aminotransferase(ALT)184.2U/L,aspartate aminotransferase(AST)319.8U/L,γ-glutamine transferase(γ-GT)79U/L,alkaline phosphatase(ALP)67.1U/L.Acute drug-induced liver injury induced by sulbenicillin was considered,therefore,the sulbenicillin was stopped.Seven days after sulbenicillin withdrawal,the values of TBil,ALT and AST were 3.4μmol/L,64U/L,27U/L,respectively.
作者
罗吉敏
张峻
LUO Ji-min;ZHANG Jun(Department of Clinical Pharmacy,First Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China)
出处
《药品评价》
CAS
2018年第8期63-64,共2页
Drug Evaluation
关键词
磺苄西林
药物性肝损伤
肾功能衰竭
Sulbenicillin
Drug-induced Liver Injury
Renal Failure
