临床药师干预对我院药品不良反应监测的影响

Influence of clinical pharmacists' intervention on the monitoring of adverse drug reaction in our hospital

目的:探讨临床药师在药品不良反应监测中的作用,为提高监测的有效性提供参考。方法:采用回顾性研究方法,收集我院临床药师干预前、干预后上报的ADR报告,按报告人、报告时间、ADR累及系统/器官、ADR转归进行统计分析。结果:临床药师干预后,ADR全年上报数量由87例增加到161例,医生上报比例由干预前的17.2%增加到77.0%(P<0.001),上报时间由干预前集中在ADR发生7 d后(64.4%)缩短为集中在ADR发生3 d以内(57.8%)。干预前、后常见的ADR累及系统/器官均为皮肤及其附件损害(分别为49.5%和37.1%)。临床药师干预后未出现ADR转归不详的报告。结论:临床药师干预可以促使ADR的上报更及时、规范,减少漏报,促进临床安全合理用药。

Objective:To investigate the effects of clinical pharmacist on adverse drug reaction(ADR)monitoring,in order to provide references for improving the effectiveness of monitoring.Methods:Retrospective method was adopted in this study.ADR reports before and after intervention were extracted and statistically analyzed according to reporter,report time,systems/organs involved in ADR and ADR outcome.Results:After intervention of clinical pharmacist,the annual number of ADR reports was increased from 87 to 161.The proportion of ADRs reproted by doctors was increased from 17.2%to 77.0%(P<0.001).After intervention,most ADRs(57.8%)were reported within 3 days after ADR occurrence while 64.4%ADRs were reproted within 7 days after ADR occurrence without intervention.Whether before or after intervention,common types of ADR were skin and its appendages damages(49.5%and 37.1%,respectively).There was no ADR with unknown outcome after the intervention.Conclusion:Clinical pharmacists'intervention could help to report ADR more timely and normatively,thus to reduce the missing report and to promote safe medication.