摘要
支气管哮喘是一类以气道重塑为病理基础的呼吸道疾病,反复的炎性浸润与组织损伤修复可导致气道重塑,目前有关气道重塑形成的机制尚不全面。研究表明,上皮间质转化在气道重塑的发生和发展过程中发挥重要作用。气道上皮可通过分泌多种因子及信号通路诱发间质转化,进而导致哮喘气道重塑。该文对上皮间质转化与哮喘气道重塑之间的研究进行综述,为临床后续哮喘治疗和研究提供参考。
Bronchial asthma is a respiratory system disease characterized by airway remodeling as a pathological basis.Repeated inflammatory infiltration and tissue damage repair can lead to airway remodeling.At present,the mechanism of airway remodeling is not comprehensive.Studies have shown that epithelial-mesenchymal transition(EMT)plays an important role in the genesis and development of airway remodeling.Airway epithelial cells can be induced to mesenchymal transition through a variety of secretion factors and signaling pathways,leading to airway remodeling in asthma.This review summarizes the study of EMT and airway remodeling in asthma,providing a reference for clinical follow-up treatment and research.
作者
魏盼
李恋曲
吴鹏
贾志荣
王晓钰
洪敏
江国荣
WEI Pan;LI Lian-qu;WU Peng;JIA Zhi-rong;WANG Xiao-yu;HONG Min;JIANG Guo-rong(College of Pharmacy,Nanjing University of Chinese Medicine,Jiangsu Key Lab for Pharmacology and Safety Evaluation of Chinese Materia Medica,Nanjing 210023,China;Suzhou Wu Men Yi Pai Research Institute, the Affiliated Suzhou Hospital of TCM of Nanjing University of TCM,Suzhou Jiangsu 215003,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2018年第5期600-603,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No81473395,81373549)
江苏省自然科学基金资助项目(NoBK20141466)
江苏省儿童呼吸疾病(中医药)重点实验室资助项目(NoJKLPRD201405)
江苏高校优势学科建设工程资助项目
关键词
气道重塑
上皮间质转化
哮喘
结构蛋白
表型转化
气道炎症
airway remodeling
epithelial-mesenchymal transition
asthma
structural protein
phenotypic transformation
airway inflammation
