摘要
三七为五加科人参属植物三七[Panax notoginseng(Burk.)F.H.Chen]的干燥根及根茎,具有滋补强壮、活血化瘀、消肿止痛、止血等功效,是被广泛应用的补益类传统中药材之一。三七总皂苷是三七的主要有效成分,人参皂苷Rg1、Rb1和三七皂苷R1等是三七总皂苷的主要活性单体。近年来,一些新药的研制开发常以三七特有的皂苷成分三七皂苷R1作为重要指标,也有大量对其药理作用的研究,揭示了三七皂苷R1对心脑血管疾病等诸多系统疾病具有防治作用,为进一步的临床应用提供了理论依据。该文主要对近年来有关三七皂苷R1药理机制的研究进行综述。
Sanqi in Chinese herbal medicine is the root and rhizoma of Panax notoginseng(Burk.)F.H.Chen.As the effects of strengthening with tonics,promoting blood circulation to remove blood stasis,relieving swelling and pain and hemostasia,it is widely used as a tonic medicine in the traditional Chinese medicine.The main active constituents of Sanqi are panax notoginseng saponins,including ginsenoside Rg1,Rb1 and notoginsenoside R1.Notoginsenoside R1 is one of the unique monomer compositions of panax notoginseng,which is often used as an ingredient indicator in new drug research and development.In current years,the scientists have been conducted tremendous fundamental studies to research the pharmacological activities of notoginsenoside R1,to reveal its protective effects on the cardiovascular system,central nervous system as well as to many other aspects.It is hoped that the relevant study about the pharmacological action of notoginsenoside R1 would help its further clinical application.This paper mainly reviews the research on the pharmacological mechanism of notoginsenoside R1 in recent years.
作者
谭亮
汤秋凯
王守章
肖井楠
樊光辉
TAN Liang;TANG Qiu-kai;WANG Shou-zhang;XIAO Jing-nan(Clinical College of Traditional Chinese Medicine,Hubei University of Chinese Medicine,Wuhan 430000,China;Dept of Neurology,Zhejiang Sian International Hospital,Jiaxing Zhejiang 314000,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2018年第5期604-607,共4页
Chinese Pharmacological Bulletin
关键词
三七
三七皂苷R1
药理作用
研究进展
心血管系统
神经系统
Notoginseng Radix Et Rhizoma
notoginsenoside R1
pharmacological action
research progress
cardiovascular system
nervous system