25602例住院儿童呼吸道腺病毒感染检出分析

Adenovirus detection in 25 602 hospitalized children with respiratory tract infection

目的研究2014-2016年间深圳地区住院患儿呼吸道腺病毒感染特点。方法选择2014年1月至2016年12月在深圳市儿童医院住院的呼吸道感染患儿25 602例,采用直接免疫荧光法对患儿鼻咽部分泌物进行腺病毒等7种病毒抗原检测,对腺病毒的检出率和临床诊断关系等进行分析。结果 25 602例标本中腺病毒抗原阳性761例,阳性率2.97%,男、女检出率分别为3.12%和2.70%,差异无统计学意义(P>0.05)。年龄为6岁以内的阳性患儿有724例(95.14%),其中2岁以内409例(53.75%)。2014-2016年中每月均有腺病毒检出,检出率高峰在夏季和冬季,明显高于春季和秋季(χ~2=36.631,P<0.05)。761例腺病毒检出阳性病例中,诊断为肺炎431例,支气管炎109例,扁桃体炎74例,咽结膜炎14例,急性上呼吸道感染133例。结论腺病毒是深圳地区住院患儿呼吸道感染的重要病原。

Objective To investigate the characteristics of adenovirus infection in hospitalized children with respiratory tract infection in Shenzhen.Methods Nasopharyngeal swabs obtained from 25 602 children hospitalized with respiratory tract infections in Shenzhen Children′s Hospital during 2014 to 2016,were tested for adenovirus with direct immunofluorescence assay.The detection rate of adenovirus and diagnosis in hospitalized children with respiratory tract infection were analyzed.Results The total adenovirus detection rate was 2.97%in 25 602 samples,with a male to female ratio of 2.04:1,no significantly difference in detection rate in male(3.12%)and female(2.70%).Accounted for 724(95.14%)of the total adenovirus positive detection children below six years old,and 409(53.75%)children were detected below two years old.There was a distinct seasonality;the detection rate was higher in summer and winter(χ2=36.631,P<0.01).In 761 hospitalized patients of ADV positive,431 were pneumonia,109 were bronchitis,74 were tonsillitis,14 were conjunctivitis pharynx and 133 were acute upper respiratory infection.Conclusion Our study demonstrates that respiratory adenovirus infection is an important cause of hospitalization in children below the age of 6 years in Shenzhen,China.The detection rate was higher in summer and winter than spring and autumn.Most adenovirus positive children were diagnosed by pneumonia,bronchitis and acute upper respiratory tract infection.