成年健康体检人群幽门螺杆菌感染与血脂异常的相关性研究

Correlation between Helicobacter pylori infections and serum lipid abnormality in adult population of healthy physical examination

目的研究昆明市成年健康体检人群中幽门螺杆菌(HP)感染与血脂异常的关系。方法回顾性分析2013年1月至2015年2月在该中心采用13 C-尿素呼气试验(13 C-UBT)进行Hp检测的昆明市成年健康体检人群资料。该资料包括调查对象基本信息,血脂指标[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)];根据有无HP感染分为HP阳性组及HP阴性组。比较两组TC、TG、HDL-C、LDL-C水平、单项血脂异常及总体血脂异常发生情况,并行二分类Logistic回归分析,探讨HP感染与血脂异常的关系。结果共纳入研究对象1 354例,HP感染率为33.2%。HP阳性与阴性两组间4种血脂水平比较差异无统计学意义(P>0.05);HP阳性组TC升高异常发生率低于HP阴性组(P<0.05);血脂异常发生率在总体及按性别、年龄、BMI分层的各层内HP阳性与阴性两组间比较差异均无统计学意义(P>0.05)。回归分析提示,HP感染为TC升高异常的独立影响因素(OR=0.644,P<0.05)。结论 HP感染影响TC升高异常的发生率,但是可能不会影响血脂异常发生率。

Objective To explore the relationship between Helicobacter pylori(HP)infection and dyslipidemia in adult people undergoing the healthy physical examination in Kunming city.Methods The intact population data of adult people undergoing the healthy physical examination and conducting the HP detection by adopting the 13 C breath test(13 C-UBT)in the Cadres Physical Examination Center,Yunnan Provincial Second People′s Hospital from January 2013 to February 2015 were retrospectively analyzed.The data included the basic information and serum lipids indexes[total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)].All subjects were divided into the HP positive group and HP negative group according to whether having HP infection.The levels of TC,TG,HDL-C,LDL-C and the incidences of single index of dyslipidemia and total dyslipidemias were compared between 2 groups and Logistic regression analysis was performed for investigating the relationship between HP infection and dyslipidemia.Results A total of 1 354 subjects were included in the study.The HP infection rate was 33.2%.The levels of TC,TG,HDL-C and LDL-C were no statistical significance between positive HP group and negative HP group(P>0.05).The incidence rate of TC≥6.22 mmol/L of HP positive group was lower than that of HP negative group(P<0.05).The occurrence rate of TC increase abnormality in the HP positive group was lower than that in the HP negative group(P<0.05);the occurrence rate of dyslipidemia had no statistical difference between the HP positive group and HP negative group in the stratification according to sex,age and BMI(P>0.05).The regression analysis showed that the HP infection was an independent influencing factors of TC increase abnormality(OR=0.644,P<0.05).Conclusion The HP infection affects the incidence of TC increase abnormality,but might not affect the occurrence rate of dyslipidemia.