生物反馈联合莫沙必利治疗慢传输型便秘的疗效观察

Clinical observation on biofeedback combined with mosapride in treatment of slow transit constipation

目的观察生物反馈联合莫沙必利治疗慢传输型便秘(STC)的临床效果。方法 108例STC患者采取随机分组方式分为3组,其中治疗A组38例给予生物反馈+莫沙必利治疗,对照B组33例给予莫沙必利+虚拟生物反馈治疗,对照C组37例给予生物反馈+安慰剂治疗。3组均治疗4周后观察疗效。结果三种不同的治疗方案均可改善慢传输型便秘患者的临床症状,提高结肠排出率,治疗A组治愈11例、显效10例、有效13例、无效4例,对照B组依次为4例、7例、4例、18例,对照C组依次为5例、7例、8例、17例。治疗A组疗效高于对照B组和对照C组(χ2=12.914,P=0.002)。治疗A组治疗后结肠排出个数明显升高,与对照组比较差异有统计学意义(P<0.05)。结论生物反馈联合莫沙必利治疗慢传输型便秘的疗效优于莫沙必利或生物反馈的单一治疗,并且能有效促进结肠排空,值得临床推广及进一步研究参考。

Objective To observe the curative effect of biofeedback combined with mosapride in treatment of slow transit constipation(STC).Methods 108 patients with STC were randomly divided into group A(n=38),group B(n=33)and group C(n=37).Group A received biofeedback in combination with mosapride;Group B received mosapride plus virtual biofeedback;Group C was treated with biofeedback plus placebo.The curative effects were compared among the three groups 4 weeks after treatment.Results The three differentnt regimens were effective to improve the patients′clinical symptoms and elevate their colon discharge rates.The curative effect of group A was superior to that of group B or group C(χ2=12.914,P=0.002).The number of colon discharge in group A was larger than that of group B or group C(P<0.05).Conclusion Biofeedback combined with mosapride is more effective in treatment of STC than a single treatment of mosapride or biofeedback therapy.It can obviously accelerate the colon emptying and is worthy of expanding further study.