参麦注射液联合奥扎格雷对急性缺血性脑卒中患者NIHSS评分及血清Hcy、LP(a)水平变化的影响

Effect of Shenmai Injection Combined with Ozagrel on NIHSS Score and Serum Levels of Hcy and LP(a) in Patients with Acute Ischemic Stroke

目的:探讨参麦注射液联合奥扎格雷对急性缺血性脑卒中(AIS)患者神经功能恢复及血清同型半胱氨酸(Hcy)、脂蛋白a[LP(a)]水平变化的影响。方法:选取2014年12月-2017年9月我院114例AIS患者,按照随机数字表法分为观察组(n=57)与对照组(n=57)。常规治疗基础上,对照组给予奥扎格雷治疗,观察组给予参麦注射液+奥扎格雷治疗,对比两组临床疗效、治疗前后血清Hcy、LP(a)水平及神经功能(NIHSS)评分,同时对比两组治疗期间不良反应发生率。结果:观察组治疗总有效率较对照组高(P<0.05);两组血清Hcy、LP(a)水平治疗前比较差异无统计学意义(P>0.05),治疗后两组血清Hcy、LP(a)水平均下降(P<0.05),且观察组血清Hcy、LP(a)水平低于对照组(P<0.05);两组NIHSS评分治疗前比较差异无统计学意义(P>0.05),治疗后两组NIHSS评分较治疗前均降低(P<0.05),且观察组较对照组低(P<0.05);观察组治疗期间不良反应发生率与对照组比较差异无统计学意义(P>0.05)。结论:给予AIS患者参麦注射液联合奥扎格雷治疗,疗效显著,可有效改善患者血清Hcy、LP(a)水平,促进神经功能恢复,且具有一定安全性。

Objective:To investigate the effect of Shenmai injection combined with ozagrel on the recovery of neurological function and the changes of serum homocysteine(Hcy)and lipoprotein a[LP(a)]levels in patients with acute ischemic stroke(AIS).Methods:A total of 114 patients with AIS from December 2014 to September 2017 in our hospital were randomly divided into the observation group(n=57)and the control group(n=57).On the basis of conventional treatment,the control group was treated with ozagrel,and the observation group was treated with Shenmai injection and ozagrel.The clinical efficacy,serum Hcy,LP(a)levels and neurological function(NIHSS)scores were compared between the two groups,and the incidence of adverse reactions during the treatment was compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group(P<0.05).There was insignificant difference in serum Hcy and LP(a)levels between the two groups before treatment(P>0.05).After treatment,serum Hcy and LP(a)levels were decreased in the two groups(P<0.05).The serum levels of Hcy and LP(a)in the observation group were lower than those in the control group(P<0.05).There was insignificant difference in NIHSS score between the two groups before treatment(P>0.05).After treatment,the NIHSS scores of the two groups were lower than before treatment(P<0.05),and the observation group was lower than the control group(P<0.05).There was insignificant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion:The treatment of Shenmai injection combined with ozagrel in patients with AIS has significant curative effect.It can effectively improve the level of serum Hcy and LP(a),promote the recovery of neurological function,and it has certain safety.