多囊卵巢综合征血清骨调素水平及对卵巢间质血流的影响研究

The Study of Serum Osteotontin Level and the Effect of Ovarian Stromal Flow in Polycystic Ovary Syndrome

目的:探讨多囊卵巢综合征(PCOS)患者血清骨调素水平,并且分析其与卵巢间质血流的关系。方法:选择2015年6月-2017年6月在我院进行诊治的PCOS患者86例作为观察组;另外选择51例同期健康体检者作为对照组。所有研究对象于卵泡早期或闭经2个月以上抽取空腹血测定黄体生成素(LH)、促卵泡刺激素(FSH)、雌二醇(E2)、孕激素(P)、泌乳素(PRL)、睾酮(T)。采用酶联免疫吸附法测定血清骨调素(OC)。所有研究对象均于采血当日监测患者双侧卵巢间质血流,计算搏动指数(PI)和阻力指数(RI)。结果:两组血清FSH、E_2、P、PRL的差异无统计学意义(P>0.05);观察组血清LH、LH/FSH、T明显高于对照组(P<0.05)。观察组患者卵巢血流PI、RI均明显低于对照组(P<0.05);观察组血清OC明显低于对照组(P<0.05)。PCOS患者血清OC与血清LH、LH/FSH、T呈负相关关系(P<0.05);血清OC与卵巢血流PI、RI呈正相关关系(P<0.05)。结论:PCOS患者血清骨调素明显降低,并且与患者卵巢间质血流有密切关系,可能通过改变机体内性激素水平而调节卵巢血流量。

Objective:To study of serum osteotontin level and the effect of ovarian stromal flow in polycystic ovary syndrome(PCOS).Methods:86 cases of PCOS patients who were treated in our hospital from June 2017 to June 2015 were selected as observation group;in addition,51 cases of healthy physical examination in the same period were selected as control group.All of the subjects in the early follicular or amenorrhea for more than 2 months of fasting blood determination of luteinizing hormone(LH),follicle stimulating hormone(FSH),estradiol(E 2)and progesterone(P),prolactin(PRL),testosterone(T).Serum Osteocalcin(OC)was determined of by enzyme-linked immunosorbent assay.All subjects were monitored on the day of blood collection,and the pulsatility index(PI)and the resistance index(RI)were calculated.Results:There was no significant difference in serum FSH,E 2,P and PRL between the two groups(P>0.05).The serum LH,LH/FSH and T in the observation group were significantly higher than those in the control group(P<0.05).The PI and RI of the ovarian blood flow in the observation group were significantly lower than that of the control group(P<0.05).The serum OC of the observation group was significantly lower than that of the control group(P<0.05).The negative correlation between serum OC and serum LH,LH/FSH and T(P<0.05)in patients with PCOS.There was a positive correlation between serum OC and ovarian blood flow PI and RI(P<0.05).Conclusion:Serum osteopontin levels in patients with polycystic ovary syndrome are significantly decreased,and are closely related to ovarian interstitial blood flow.It may regulate ovarian blood flow by changing the level of sex hormones in the body.