尿酸与心房颤动

Uric acid and atrial fibrillation

心房颤动(AF)是最常见的心律失常,而我国人群中高尿酸血症(HUA)患病率高达13%,多项研究提示HUA是AF新发、复发的危险因素。一方面,HUA可能通过氧化应激、炎症、细胞内尿酸的聚积从而导致心房电重构、机械重构的发生,进而促进AF的发生;另一方面,低尿酸血症亦可导致AF,血清尿酸水平与AF之间似乎呈现J型曲线关系。

Atrial fibrillation(AF)is the most common arrhythmia.The prevalence of hyperuricemia(HUA)is up to 13%in Chinese population.Many studies have suggested that HUA is a risk factor for new-onset and recurrence AF.On the one hand,HUA may induce electrical and mechanical remodeling of atrial through oxidative stress,inflammation and accumulation of uric acid in the cells,thereby promoting the occurrence of AF;on the other hand,hypouricemia can also lead to AF.The relationship between serum uric acid level and AF appears to be a J type curve.