色素上皮衍生因子与动脉粥样硬化相关性的研究进展

Research progress on correlation between pigment epithelium-derived factor and atherosclerosis

随着人们生活水平的不断进步,动脉粥样硬化(AS)日益成为危害人类健康的杀手。炎症反应和氧化应激是AS发展的关键步骤,血栓形成和新生血管生成与AS斑块不稳定密切相关,甚至引发AS斑块破裂和急性冠状动脉综合征。目前研究表明,色素上皮衍生因子(PEDF)具有抗炎、抗氧化、抗血管新生和抑制血栓形成等特性,对AS发挥保护作用。本文就PEDF与AS之间关系的研究进展做一综述。

With the improvement of people s living quality,atherosclerosis(AS)has increasingly become an threatening factor of human health.Inflammation and oxidative stress are key steps in the development of AS.Thrombosis and neovascularization are closely related to the instability of the AS plaques,which lead to plaque rupture and acute coronary syndrome.Current studies have shown that pigment epithelial derived factor(PEDF)has anti-inflammatory,anti-oxidative,anti-angiogenesis and anti-thrombotic properties and play a protective role in AS.The research progress on the relationship between pigment epithelium derivatives and AS will be reviewed in this article.