~1H-MRS对结核性脑炎代谢物的检测价值分析

~1H-MRS Detection for Tuberculosis Encephalitis Metabolites

目的探讨结核性脑炎代谢物的磁共振波谱(1H-MRS)检测的临床意义。方法对43例临床确诊为结核性脑炎的患者行增强MRI检查,然后采用二维多体素磁共振波谱(1H-MRS)技术对包括病变区、病灶周围水肿区及健侧对照区进行代谢物浓度分析,P<0.05被认为有统计学差异。结果结核性脑炎强化病灶区、病灶周围水肿区与其健侧正常区的代谢物NAA/Cr、NAA/Cho和Cho/Cr比值比较,均有统计学差异;结核性脑炎强化病灶区与周围水肿区的代谢物Cho/Cr比值比较,有统计学差异,而NAA/Cr和NAA/Cho值比较,无统计学差异。结论氢质子磁共振波谱技术能够检测结核性脑炎代谢物浓度的变化,为结核性脑炎的不同病理代谢物浓度变化提供定量依据,是常规MRI的重要补充。

Objective To investigate the clinical effects of magnetic resonance spectroscopy(1H-MRS)detection of tuberculous encephalitis metabolites.Methods Forty-three patients with tuberculous encephalitis were enrolled in this study.Two-dimensional multi-voxel magnetic resonance spectroscopy(1H-MRS)was used to study the effects of the lesion area,the surrounding area of the lesion and the contralateral control area Metabolite concentration analysis(P<0.05)was considered statistically significant.Results There were significant differences in NAA/Cr,NAA/Cho and Cho/Cr ratios between tuberculous encephalitis-enriched lesion area,surrounding edema area and its healthy normal area.The tuberculous encephalitis intensified lesion area There was no significant difference between the NAA/Cr and NAA/Cho values,and there was no significant difference in the ratio of Cho/Cr of metabolites in the surrounding edema area.Conclusion Hydrogen proton magnetic resonance spectroscopy can detect the changes of metabolites in tuberculous encephalitis and provide quantitative basis for the changes of different pathological metabolites of tuberculous encephalitis,which is an important supplement to conventional MRI.