促红细胞生成素肝细胞激酶受体及配体对骨改建的调控作用

Regulatory Effects of Erythropoietin-producing Hepatocyte Kinase Receptor and Ephrin Ligand on Bone Remodeling

在骨改建过程中,破骨细胞和成骨细胞相互作用以维持骨吸收和骨形成的平衡。研究表明促红细胞生成素肝细胞激酶受体及其配体介导的双向信号传导可调控成骨-破骨细胞间的耦联作用,本文主要综述Eph家族蛋白的分子结构、信号转导机制,及其调控骨改建、牙槽骨改建等。

During the process of bone remodeling,the bone homeostasis is tightly controlled by the coupling of bone resorption and bone formation,depending upon cellular communication between osteoclasts and osteoblasts.Many studies have identified that the bi-directional transduction of erythropoietin producing hepatocyte kinase receptor and ephrin ligand(Eph/ephrin)is one of signal transduction pathways in bone remodeling.This review focus on the potential role of Eph/ephrin in bone remodeling,especially in alveolar remodeling.