颞叶内侧癫痫智力损害与发作间期痫样放电扩散区域的相关性

The study of relationship between intelligence impairment and interictal epileptiform discharges spreading in mesial temporal lobe epilepsy

目的探讨颞叶内侧癫痫患者智力损害与发作间期痫样放电扩散区域的关系。方法纳入颞叶内侧癫痫患者145例,收集一般临床资料,分析智力损害与发作间期痫样放电区域关系。结果 (1)颞叶内侧癫痫患者病程越长、发作频率越高,总体智商、言语智商及操作智商损害越明显;起病年龄越小,总体智商越下降明显。(2)左侧颞叶内侧癫痫患者发作间期痫样电波及左侧中央区、顶区与智商呈负相关;右侧颞叶内侧癫痫患者发作间期痫样电波放电波及右额区与操作智商呈负相关,而波及右枕区则呈正相关。结论 (1)颞叶内侧癫痫患者智力损害与病程及发作频率相关;(2)左侧颞叶内侧癫痫患者发作间期异常放电波及同侧中央、顶区时更容易造成智力损害,而右侧颞叶内侧癫痫患者发作间期痫样电波放电波及右额区时,操作智商损害更明显。

Objective To investigate the relationship between intelligence impairment and interictal epileptiform discharges spreading in mesial temporal lobe epilepsy(mTLE)patients.Method We assessed 145 patients diagnosed as mTLE and their general materials,analyzed the relationship between intelligence impairment and interictal epileptiform discharges spreading.Results①Patients with mTLE with longer disease course and higher frequencies of epilepsy tended to have a severe impairment in the total intelligence quotient(IQ),verbal intelligence quotient(vIQ)and performance intelligence quotient(pIQ).②IQ of was negatively correlated with the condition that interictal epileptiform discharges spreading to the ipsilateral central and parietal region in patients with left lesion;pIQ was negatively correlated with the condition that interictal epileptiform discharges spreading to the ipsilateral frontal region,while positively correlated with the condition that interictal epileptiform discharges spreading to the ipsilateral occipital region in patients with right lesion.Conclusion①Intelligence impairment of mTLE patients is related with courses and frequencies.②Total IQ is more severely impaired by interictal epileptiform discharges spreading to the ipsilateral central and parietal region in left mTLE patients,and the pIQ is more severely impaired by interictal epileptiform discharges spreading to the ipsilateral frontal region in right mTLE patients.